Recent work in the embryonic stem cell (ESC) field has focused on the transcriptional and epigenetic control of mESC pluripotency and self-renewal. However, it is not yet clear how a mESC decides on a certain cell fate and differentiates to a specific embryonic lineage. Prior studies showed that mESC chromatin landscape is kept in a relatively open conformation, signifying the potential for various cell fates. However, lineage specific genes should be truthfully activated at the right time and location during early embryonic development. NTC Lab is interested in the chromatin factors that play critical roles in the transformation of pluripotent mESCs toward restricted cell types